Copyright (c) 2009 California Polytechnic State University All rights reserved. http://digitalcommons.calpoly.edu Recent documents in DigitalCommons@CalPoly en-us Sun, 22 Nov 2009 05:51:21 PST 3600 http://digitalcommons.calpoly.edu/theses/189 http://digitalcommons.calpoly.edu/theses/189 Fri, 20 Nov 2009 10:21:03 PST A microfluidic device was created for single-cell capture and analysis using polydimethylsiloxane (PDMS) channels and a glass substrate to develop a microfluidic single-cell impedance sensor for cell diagnostics. The device was fabricated using photolithography to create a master mold which in turn will use soft lithography to create the PDMS components for constant device production. The commercial software, COMSOLTM Multiphysics, was used to quantify the fluid dynamics in shallow micro-channels. The device will be able to capture a cell and sequester it long enough to enable measurement of the impedance spectra that can characterize cell. The proposed device will be designed to capture a single cell and permit back-flow to flush out excess cells in the chamber. The device will be designed to use syringe pumps and the syringe-controlled channel will also be used to capture and release the cell to ensure cell control and device reusability. We hypothesize that these characteristics along with other proposed design factors will result in a unique microfluidic cell-capture device that will enable single-cell impedance sensing and characterization. Joshua-Jed Doria Fadriquela http://digitalcommons.calpoly.edu/mll_fac/28 http://digitalcommons.calpoly.edu/mll_fac/28 Thu, 19 Nov 2009 14:57:02 PST Brian G. Kennelly http://digitalcommons.calpoly.edu/ceng_dean/31 http://digitalcommons.calpoly.edu/ceng_dean/31 Wed, 18 Nov 2009 16:02:21 PST Cal Poly College of Engineering http://digitalcommons.calpoly.edu/theses/188 http://digitalcommons.calpoly.edu/theses/188 Wed, 18 Nov 2009 14:09:50 PST The Cardiac Rhythm Management Division of St. Jude Medical specializes in the development of implantable cardioverter defibrillators that improve the quality of life for patients diagnosed with a variety of cardiac arrhythmias, especially for patients prone to sudden cardiac death. With the goal to improve detection of cardiac arrhythmias, this study explored the value in time-frequency analysis of intracardiac electrogram in four steps. The first two steps characterized, in the frequency domain, the waveforms that construct the cardiac cycle. The third step developed a new algorithm that putatively provides the least computationally expensive way to identifying cardiac waveforms in the frequency domain. Lastly, this novel approach to analyzing intracardiac electrogram was compared to a threshold crossing algorithm that strictly operates in the time domain and that is currently utilized by St. Jude Medical. The new algorithm demonstrated an equally effective method in identifying the QRS complex on the ventricular channel. The next steps in pursing time-frequency analysis of intracardiac electrogram include implementing the new algorithm on a testing platform that emulates the latest implantable cardioverter defibrillator manufactured by St. Jude Medical and pursuing a similar algorithm that can be employed on the atrial channel. Erik Brockman http://digitalcommons.calpoly.edu/ceng_dean/30 http://digitalcommons.calpoly.edu/ceng_dean/30 Wed, 18 Nov 2009 13:50:55 PST Cal Poly College of Engineering http://digitalcommons.calpoly.edu/ceng_dean/28 http://digitalcommons.calpoly.edu/ceng_dean/28 Wed, 18 Nov 2009 13:47:25 PST Cal Poly College of Engineering http://digitalcommons.calpoly.edu/ceng_dean/29 http://digitalcommons.calpoly.edu/ceng_dean/29 Wed, 18 Nov 2009 13:47:25 PST Cal Poly College of Engineering http://digitalcommons.calpoly.edu/ceng_dean/27 http://digitalcommons.calpoly.edu/ceng_dean/27 Wed, 18 Nov 2009 13:47:22 PST Cal Poly College of Engineering http://digitalcommons.calpoly.edu/engl_fac/28 http://digitalcommons.calpoly.edu/engl_fac/28 Wed, 18 Nov 2009 13:26:26 PST Mary A. Armstrong http://digitalcommons.calpoly.edu/engl_fac/27 http://digitalcommons.calpoly.edu/engl_fac/27 Wed, 18 Nov 2009 13:26:25 PST Mary A. Armstrong http://digitalcommons.calpoly.edu/mesp/1 http://digitalcommons.calpoly.edu/mesp/1 Tue, 17 Nov 2009 11:05:47 PST AbstractThe project described herein is a senior design project for mechanical engineering students. This report details the design, build, and test process for the development of a wheelchair hand cycle attachment that drives the wheels of the wheelchair, rather than the wheel of the attachment. The sponsor of the project, Mr. Greg O'Kelly is interested in such a device for his own use as well as having a working prototype as a "proof of concept", should the design be successful enough to manufacture. From the sponsor's perspective, in addition to acquiring a product he can use, this is also an opportunity to offer real world experience to a team of engineering students through the development of a solution to an existing problem. There are six students working internationally to develop a single final product; three students in the United States attending California Polytechnic State University, and three students in Germany, attending the Hochschule München, School of Applied Sciences. From the student's perspective, this is meant to be a capstone experience- the culmination of their engineering education, and a bridge between the academic world of theory and the professional world of actual product development. This report covers the background for the project, design development, an in-depth description of the final design, a testing plan, a project management plan, and the conclusion to date. Colin Neunuebel http://digitalcommons.calpoly.edu/stockreport/vol6/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol6/iss1/1 Tue, 17 Nov 2009 10:36:45 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol5/iss2/1 http://digitalcommons.calpoly.edu/stockreport/vol5/iss2/1 Tue, 17 Nov 2009 10:36:44 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol5/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol5/iss1/1 Tue, 17 Nov 2009 10:36:44 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol4/iss2/1 http://digitalcommons.calpoly.edu/stockreport/vol4/iss2/1 Tue, 17 Nov 2009 10:36:43 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol4/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol4/iss1/1 Tue, 17 Nov 2009 10:36:42 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol3/iss3/1 http://digitalcommons.calpoly.edu/stockreport/vol3/iss3/1 Tue, 17 Nov 2009 10:36:42 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol3/iss2/1 http://digitalcommons.calpoly.edu/stockreport/vol3/iss2/1 Tue, 17 Nov 2009 10:36:41 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol3/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol3/iss1/1 Tue, 17 Nov 2009 10:35:34 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol2/iss3/1 http://digitalcommons.calpoly.edu/stockreport/vol2/iss3/1 Tue, 17 Nov 2009 10:35:33 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol2/iss2/1 http://digitalcommons.calpoly.edu/stockreport/vol2/iss2/1 Tue, 17 Nov 2009 10:35:05 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol2/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol2/iss1/1 Tue, 17 Nov 2009 10:35:04 PST Animal Science Department California Polytechnic State University http://digitalcommons.calpoly.edu/stockreport/vol1/iss1/1 http://digitalcommons.calpoly.edu/stockreport/vol1/iss1/1 Tue, 17 Nov 2009 10:35:03 PST Animal Science Department California Polytechnic State University